Abstract #4764
Tract-based assessment of the subcortical motor network plasticity after stroke
Silvia Obertino 1 , Ying-Chia Lin 2 , Alessandro Daducci 3 , Jean-Philippe Thiran 3 , Reto Meuli 4 , Gunnar Krueger 5 , Cristina Granziera 4 , and Gloria Menegaz 1
1
Computer Science, University of Verona,
Verona, Select, Italy,
2
Computer
Science, University of Verona, Italy,
3
Swiss
Federal Institute of Technology (EPFL), Switzerland,
4
CHUV,
Lausanne, Switzerland,
5
Siemens,
Switzerland
This study aimed at investigating myelin and axonal
plasticity in the subcortical motor networks (SC-MN)
contralateral to stroke by applying diffusion spectrum (DSI)
and magnetization transfer (MT) imaging. Ten patients
and ten HC underwent DSI scans. Generalized Fractional
Anisotropy (GFA) was derived from DSI scans and
Magnetization transfer ratio (MTR) values were
calculated as percent of the ratio (MT-M0)/M0 for each
fiber. Both histogram features (mean, variance, skewness,
kurtosys, peak hight, peak position) and measures of
histogram distances were used for between group
comparisons. Results suggest both short term (1 month)
and mid term (6 months) axonal and myelin plasticity in
the uninjured cortico-subcortical motor circuits.
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