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Abstract #4706

Longitudinal DTI Study in Parkinson's Disease

Ling Ling Chan 1,2 , Helmut Rumpel 1 , Kia Min Ng 2 , Chooi Sum Yeoh 1 , and Eng King Tan 2,3

1 Singapore General Hospital, Singapore, Singapore, 2 Duke-NUS Graduate Medical School, Singapore, Singapore, 3 National Neuroscience Institute, Singapore

This longitudinal case control DTI study evaluated the rate of change in FA and ADC in Parkinsons disease over a 5 year period. We found an increased FA and ADC in the basal ganglia and substantia nigra. There was a significant difference in the rate of change in the DTI parametrics in the putamen, thalamus, substantia nigra and frontal white matter between PD and controls. The increased FA of gray nuclei in PD over time was unexpected and possibly related to iron deposition. The rate of DTI changes over time may be useful as potential imaging markers of disease progression.

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