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Abstract #4705

Mapping Gray Matter Structural Integrity in Adults Perinatally infected with HIV

Varan Govind 1 , Anai Cuadra 2 , Elizabeth Willen 2 , M Judy D Post 1 , Kristopher Arheart 3 , and Sulaiman Sheriff 1

1 Radiology, University of Miami, Miami, Florida, United States, 2 Pediatrics, University of Miami, Miami, Florida, United States, 3 Epidemiology and Public Health, University of Miami, Miami, Florida, United States

The long term impact of HIV infection and the potential effects of its therapeutics on the brain are not completely characterized. Previous brain imaging studies have assessed only the changes in white matter and some deep gray matter structures. In this study, all gray matter structures within the brain are evaluated using diffusion kurtosis imaging metrics in adults perinatally infected with HIV and a matched control group for comparisons. The results indicate significant changes in 19 of the 60 gray matter structures evaluated. These changes may indicate underlying pathologies responsible for HIV-associated neurocognitive disorder (HAND) in people with HIV infection.

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