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Abstract #4681

Oxygenation responses to an autonomic challenge in the elderly estimated with the means of quantitative fMRI. Is the white matter at risk of hypoxic injury?

Iwo Jerzy Bohr 1 , Claire McDonald 2 , Jiabao He 3 , Simon Kerr 4 , Julia Newton 5 , and Andrew M Blamire 1

1 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2 Newcastle University, United Kingdom, 3 Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 4 Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, 5 Clinical Academic Office, Newcastle University, Newcastle upon Tyne, United Kingdom

Hypoxic ischemia is considered to be a major factor contributing to formation of age-related white matter lesion. We hypothesize that transient hypoxic episodes caused for instance by standing could contribute to this process. Using quantitative fMRI (measuring effective transverse relaxation rate; R2*) we investigated the brain areas particularly vulnerable to transient hypoxia during performance of Valsava manoeuvre (VM). We employed general linear model to estimate the impact of VM on R2*. We found that deoxygenation statistical map overlapped strongly with watershed region between the middle cerebral and posterior artery perfusion territories.

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