Abstract #4681
Oxygenation responses to an autonomic challenge in the elderly estimated with the means of quantitative fMRI. Is the white matter at risk of hypoxic injury?
Iwo Jerzy Bohr 1 , Claire McDonald 2 , Jiabao He 3 , Simon Kerr 4 , Julia Newton 5 , and Andrew M Blamire 1
1
Newcastle Magnetic Resonance Centre,
Newcastle University, Newcastle upon Tyne, United
Kingdom,
2
Newcastle
University, United Kingdom,
3
Aberdeen
Biomedical Imaging Centre, University of Aberdeen,
Aberdeen, United Kingdom,
4
Institute
for Ageing and Health, Newcastle University, Newcastle
upon Tyne, United Kingdom,
5
Clinical
Academic Office, Newcastle University, Newcastle upon
Tyne, United Kingdom
Hypoxic ischemia is considered to be a major factor
contributing to formation of age-related white matter
lesion. We hypothesize that transient hypoxic episodes
caused for instance by standing could contribute to this
process. Using quantitative fMRI (measuring effective
transverse relaxation rate; R2*) we investigated the
brain areas particularly vulnerable to transient hypoxia
during performance of Valsava manoeuvre (VM). We
employed general linear model to estimate the impact of
VM on R2*. We found that deoxygenation statistical map
overlapped strongly with watershed region between the
middle cerebral and posterior artery perfusion
territories.
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