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Abstract #4635

High Resolution Imaging of the deep cerebellar nuclei at 7Tesla

Mike Bruegger 1,2 , Michael Wyss 1 , Bernd Daeubler 3 , Daniel Nanz 4 , Alex Ringenbach 5 , David Brunner 1 , and Klaas Pruessmann 1

1 Institute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland, 2 Center of Dental Medicine, University of Zurich, Zurich, Zurich, Switzerland, 3 Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 4 Department of Radiology, University Hospital Zurich, Zurich, Switzerland, 5 Institute for Medical and Analytical Technologies, University of Applied Sciences of Northwestern Switzerland, Muttenz, Basel, Switzerland

The deep cerebellar nuclei (dentate, fastigial, globose, emboliforme) are of significant functional importance, but difficult to investigate in detail non-invasively because of their small size and tight arrangement. This work presents a modified 3D-MPRAGE sequence with high spatial resolution (voxel size=0.275mm3) in the gray matter nulling regime at 7T. Focusing on the dentate nuclei (DN) bilaterally, we aimed to contribute to the ongoing debate linking handedness, size and hemispheric asymmetry by examining 26 healthy volunteers (13 right/left handed). We revealed a significantly smaller left DN irrespective of handedness, age and sex.

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