Abstract #4629
Visualization of Intra-Thalamic Anatomy with White-Matter-nulled MPRAGE at 7T
Thomas Tourdias 1,2 , Manojkumar Saranathan 2 , Ives R Levesque 2 , Jason Su 2 , and Brian K Rutt 2
1
Service de NeuroImagerie Diagnostique et
Thrapeutique, CHU Pellegrin - Universit de Bordeaux,
Bordeaux, France,
2
Department
of Radiology, Stanford University, Stanford, California,
United States
We present a 3D-MPRAGE pulse sequence at 7T specifically
optimized to visualize the thalamic anatomy. Simulations
of the MPRAGE signal behavior using our intra-thalamic
T1 measurements and empirical optimization in volunteers
showed that (i) nulling the signal of the white matter
(WM), (ii) increasing the time between two inversion
pulses, (iii) increasing the length of the readout, and
(iv) using a low flip angle provided the best tradeoff
between thalamic signal, intra-thalamic contrast while
limiting the blur. This method allowed to accurately and
reproducibly delineate 15 thalamic nuclei in healthy
controls.
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