Abstract #4628
Hippocampal Shape Analysis in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: The Effect of Cranial Radiotherapy
Qing Ji 1 , John O. Glass 1 , Michelle N. Edelmann 2 , Kevin R. Krull 2 , Robert J. Ogg 1 , and Wilburn E. Reddick 1
1
Radiological Science, St.Jude Children's
Research Hospital, Memphis, TN, United States,
2
Epidemiology
& Cancer Control, St.Jude Children's Research Hospital,
Memphis, TN, United States
Hippocampal volume and shape were examined in two groups
of adult survivors of childhood ALL and compared to
healthy controls using the SPHARM statistical shape
model. Survivors were treated with either only
chemotherapy or cranial radiotherapy (CRT) and
chemotherapy. The mean hippocampal volumes of both
survivor groups were lower than that of healthy
controls, but did not reach statistical significance.
Abnormal shape deformations were found primarily in the
right hippocampus of survivors treated with CRT. Since
the shape abnormality may correlate with hippocampal
damage, the results of this study suggest that radiation
may cause more damage to the hippocampi than
chemotherapy alone in adult survivors of childhood ALL.
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