Abstract #4617
Amide proton transfer (APT) imaging of brain infection in children
hong zhang 1,2 , Xuna Zhao 3 , Jinyuan Zhou 2 , and Yun Peng 4
1
Imaging Center,Beijing Childrens Hospital,
Capital Medical University, Beijing, Beijing, China,
2
Neurosection,
Division of MR Research, Department of Radiology, Johns
Hopkins University, Baltimore, MD, United States,
3
Peking
University, Beijing, China,
4
Beijing
Childrens Hospital, Capital Medical University,
Beijing, Beijing, China
APT-MRI is a chemical exchange saturation transfer
(CEST) based approach in which the amide protons of
endogenous proteins and peptides are irradiated to
accomplish detection using the water signal. In this
study, the APT approach was incorporated with standard
brain MRI sequences and applied to children with brain
infection at 3T. The initial results show that APT
imaging can enhance the noninvasive identification of
tissue heterogeneity in brain infection.
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