Abstract #4616
Assessment of Brain Damage and Plasticity in the Visual System after Early Occipital Injury: Comparison of FDG-PET with Diffusion MRI Tractography
Jeong-Won Jeong 1 , Joseph Shin 2 , Vijay N Tiwari 2 , Harry T Chugani 1 , and Csaba Juhasz 1,2
1
Pediatrics and Neurology, Wayne State
University, Detroit, Michigan, United States,
2
PET
center, Children's Hospital of Michigan, Detroit,
Michigan, United States
The present study combined DWI streamline tractography
with FDG-PET to determine the relation between occipital
cortical metabolic changes and abnormalities of the
corresponding visual tracts in children with unilateral
Sturge-Weber syndrom (SWS). We found that decreased
occipital glucose metabolism is associated with
decreased visual streamline volume on the affected
hemisphere. We also found that high glucose metabolism
in the contralateral occipital (visual) cortex is
associated with high DWI streamline volume of the
corresponding visual pathway. This study demonstrates
that FDG-PET combined with DWI tractography can be
utilized to investigate both brain damage and plasticity
in children with early occipital lesion.
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