Abstract #4607
Impaired white matter development in extremely low birth weight infants with previous brain hemorrhage
Xiawei Ou 1 , Raghu Ramakrishnaiah 1 , Charles Glasier 1 , Sarah Mulkey 1 , Zhaohua Ding 2 , and Jeffrey Kaiser 3
1
Unversity of Arkansas for Medical Sciences,
Little Rock, AR, United States,
2
Vanderbilt
University, TN, United States,
3
Baylor
College of Medicine, TX, United States
The purpose of this study is to evaluate white matter in
extremely low birth weight (ELBW) infants with or
without previous hemorrhage in the brain. We enrolled
ELBW infants for MRI examination at term-equivalent age
and reviewed their medical records of IVH diagnosis by
routine ultrasound, divided them to different groups
according to the extent of hemorrhage, and compared
their white matter respectively to healthy newborn term
infants by conventional MRI and DTI. Our results
suggested that previous hemorrhage in the brain has
significant effects on white matter development in ELBW
infants at term-equivalent age, and that ELBW infants
with no brain hemorrhage are more likely to have normal
white matter development.
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