Abstract #4606
The Effect of Maternal Substance Abuse on Fetal Brain Growth
Devasuda Anblagan 1,2 , Kaiming Yin 1 , Rebecca M Reynolds 3 , Fiona Denison 2 , Mark E Bastin 4 , Colin Studholme 5 , James P Boardman 2 , Scott I Semple 1,3 , Neil Roberts 1 , and Jane E Norman 2
1
Clinical Research Imaging Centre, University
of Edinburgh, Edinburgh, United Kingdom,
2
MRC
Centre for Reproductive Health, University of Edinburgh,
Edinburgh, United Kingdom,
3
Centre
for Cardiovascular Sciences, University of Edinburgh,
Edinburgh, United Kingdom,
4
Centre
for Clinical Brain Sciences, University of Edinburgh,
Edinburgh, United Kingdom,
5
Department
of Pediatrics, University of Washington, Seattle,
Washington, United States
Retrospective motion correction is now possible for
fetal brain MRI at 2nd and 3rd trimester, making it
possible to quantify brain development in utero. The
Isotropic Cavalieri method has been applied to analyse
3D reconstructed fetal brain images from 3638 weeks to
measure brain growth in fetuses exposed to maternal
substance abuse compared with non-exposed fetuses. Fetal
intracranial and cerebral volumes were reduced by
maternal substance abuse, and cerebellum volume and pial
surface area in female exposed fetuses are significantly
smaller compared with male exposed fetuses. Analyses
will be extended to include fetal brain measurement at
2427 weeks.
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