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Abstract #4598

Generalized Central Volume Principle for Recirculation with Contrast Elimination

Jeiran Jahani 1 , Glyn Johnson 1 , Valerij G Kiselev 2 , and Dmitry S Novikov 1

1 Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York City, New York, United States, 2 Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Quantitative perfusion analysis using bolus passage is compromised by tracer recirculation. As an alternative to the commonly used first bolus selection, we focus on relating the recirculation boluses in the brain to the topology and quantitative properties of the circulation in the whole organism. The classical central volume principle is generalized for the recirculation and the presence of contrast elimination from the blood pool. Our analytical approach makes use of treating each organs response in the frequency domain, similar to complex admittance in linear circuits. The simplest among realistic models of circulation is selected according to the data fitting quality.

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