Abstract #4586
Estimation of R1 changes from Dual bolus DCE-MRI in Vestibular Schwannomas and Meningiomas of Patients Undergoing Treatment of Bevacizumab
Xiaoping Zhu 1 , Sha Zhao 2 , Ka-Loh Li 1 , and Alan Jackson 1
1
Wolfson Molecular Imaging Centre, University
of Manchester, Manchester, United Kingdom,
2
Imaging
Science and Biomedical Engineering, University of
Manchester, Manchester, United Kingdom
In dual-bolus-DCE-MRI, R1 values prior to the main-dose
(R1init) were estimated in NF2 patients. R1init are
significantly larger than native R1 (R1N) in vascular
schwannomas and meningiomas, but not in normal brain
tissue. R1init estimated from prebolus kinetic analysis
showed close to those derived from variable flip angle
(VFA)-GRE sequences. The R1N and R1init maps from VFA
were then used in kinetic analysis of prebolus and
main-dose DCE data respectively. The Ktrans from
prebolus (one-fifth dose) were comparable to those from
high spatial resolution main-dose data, achieving the
same detection of changes in the brain tumors induced by
VEGF-blockade.
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