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Abstract #4580

DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model vs. shutter-speed model. Initial experience.

Guido Hugo Jajamovich 1 , Wei Huang 2 , Cecilia Besa 1 , Xin Li 2 , Aneela Afzal 2 , Hadrien Dyvorne 1 , and Bachir Taouli 1

1 Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2 Oregon Health & Science University, Portland, OR, United States

This study quantifies hepatocellular carcinoma (HCC) and background parenchyma perfusion parameters with DCE-MRI using two pharmacokinetic models: the Tofts Model (TM) and the Shutter-Speed Model (SSM). Parameters ve and kep from the TM and Ktrans and τi from the SSM showed significant differences between liver parenchyma and HCC, with better parameter reproducibility in liver parenchyma compared to HCC for both models and with the SSM showing worse reproducibility overall. The differences in τi may possibly reflect differences in metabolic activity between the two tissues, suggesting potential utility of this parameter for HCC characterization.

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