Abstract #4579
In vivo quantification of blood water R 1 change during hypercarbic hyperoxia
Lindsey M Dethrage 1 , Carlos C Faraco 1 , Megan K Strother 1 , and Manus J Donahue 1
1
Vanderbilt University, Nashville, Tennessee,
United States
The purpose of this study is to quantify the change in
blood water R
1
that
results from hypercarbic hyperoxia (i.e., carbogen)
administration in humans. Owing to the
small-to-negligible effect of hyperoxia on CBF, it is
possible to fit for the blood water R
1
change
during carbogen administration by performing sequential
experiments with 5%CO
2
/21%O
2
/74%N
2
and
5%CO
2
/95%O
2
. Results reveal that
blood water R
1
increases
from 0.62 at baseline (21% O
2
) to
0.73+/-0.07s
-1
during
carbogen breathing.
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