Abstract #4567
A Novel Sequence to Simultaneously Measure R2, R2* and Perfusion
Jason Kaig Mendes 1 , Christopher J Hanrahan 1 , Jeff L Zhang 1 , Gwenael Layec 2 , Corey Hart 2 , and Vivian S Lee 2
1
Radiology, University of Utah, Salt Lake
City, UT, United States,
2
Medicine,
University of Utah, Salt Lake City, UT, United States
The severity and treatment success of peripheral
arterial disease (PAD) has been correlated with the
integrity of peripheral vasculature. Muscle perfusion
and tissue oxygenation are indicators of microvascular
function and can be non-invasively measured using
blood-oxygen-level dependent (BOLD) and pulsed arterial
spin labeling (PASL) techniques. However, there is
compelling evidence that quantification of multiple
parameters may improve diagnosis and treatment response
of PAD. In particular, muscle spin lattice relaxation
(R2) can be used to more accurately quantify perfusion
and tissue oxygenation in conjunction with BOLD and PASL
data. We propose an adaptation of a current BOLD-PASL
sequence which combines R2, BOLD and ASL techniques (RBASL)
to simultaneously measure R2, R2* and perfusion.
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