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Abstract #4567

A Novel Sequence to Simultaneously Measure R2, R2* and Perfusion

Jason Kaig Mendes 1 , Christopher J Hanrahan 1 , Jeff L Zhang 1 , Gwenael Layec 2 , Corey Hart 2 , and Vivian S Lee 2

1 Radiology, University of Utah, Salt Lake City, UT, United States, 2 Medicine, University of Utah, Salt Lake City, UT, United States

The severity and treatment success of peripheral arterial disease (PAD) has been correlated with the integrity of peripheral vasculature. Muscle perfusion and tissue oxygenation are indicators of microvascular function and can be non-invasively measured using blood-oxygen-level dependent (BOLD) and pulsed arterial spin labeling (PASL) techniques. However, there is compelling evidence that quantification of multiple parameters may improve diagnosis and treatment response of PAD. In particular, muscle spin lattice relaxation (R2) can be used to more accurately quantify perfusion and tissue oxygenation in conjunction with BOLD and PASL data. We propose an adaptation of a current BOLD-PASL sequence which combines R2, BOLD and ASL techniques (RBASL) to simultaneously measure R2, R2* and perfusion.

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