Meeting Banner
Abstract #4566

What Is the Ideal Labeling Duration for Pseudocontinuous Arterial Spin Labeling?

Zungho Zun 1 , R. Marc Lebel 2 , Ajit Shankaranarayanan 3 , and Greg Zaharchuk 1

1 Stanford University, Stanford, CA, United States, 2 GE Healthcare, Calgary, AB, Canada, 3 GE Healthcare, Menlo Park, CA, United States

A recent arterial spin labeling (ASL) white paper recommends pseudocontinuous ASL (PCASL) with labeling duration (LD)/post-labeling delay (PLD) of 1.8/2.0 s for clinical applications. Compared to PLD, there has been little exploration in optimization of LD. In this study, CBF measurement was performed in volunteers using PCASL with different LD, and ASL signal-to-noise ratio (SNR) efficiency was compared among scans with different LD. Measured SNR efficiency showed good agreement with simulation and was maximized when LD was 3-4 s, achieving about 30% gain compared to LD = 1.5 s. Potential reduction in apparent CBF measurement with prolonged LD was not found.

This abstract and the presentation materials are available to members only; a login is required.

Join Here