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Abstract #4536

Enhanced Contrast of Ischemic Stroke Lesions in Non-Gaussian Diffusion Imaging

Farida A. Grinberg 1 , Ezequiel Farrher 1 , Luisa Ciobanu 2 , Franoise Geffroy 2 , Denis Le Bihan 2 , and N. Jon Shah 1,3

1 Forschungszentrum Juelich, Juelich, Germany, 2 Neurospin, CEA, France, 3 RWTH Aachen University, Germany

We compare a sensitivity of two non-Gaussian diffusion models with the gold standard ADC approach in providing the contrast for ischemic lesions in animals: the stretched-exponential and gamma-distribution functions. Both functions provide good fits in the extended range of the diffusion weightings and allow for an enhanced contrast of the lesions. An interesting finding of this work is the appearance of laminar cortical structures in stroke lesions clearly visualised by the parameter maps of the investigated models but hardly observable in the ADC-maps.

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