Abstract #4535
Differences in diffusional changes of the optic pathways between Multiple Sclerosis and Neuromyelitis Optica using Diffusional Kurtosis Imaging
Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2
1
Department of Radiology, Juntendo University
School of Medicine, Bunkyo, Tokyo, Japan,
2
Department
of Neurology, Juntendo University School of Medicine,
Tokyo, Japan,
3
Division
of Radiology and Biomedical Engineering, Graduate School
of Medicine, The University of Tokyo, Tokyo, Japan
The purpose of this study is to evaluate differences in
diffusional changes of the optic pathways between
multiple sclerosis (MS) and neuromyelitis optica (NMO)
using a new method, diffusional kurtosis imaging (DKI)
Six NMO, eight MS, and seven healthy volunteers
participated in this study. DKI sensitively detected
abnormalities in optic tract in NMO patients. According
to the past reports, NMO-immunoglobulin G targeting AQP4
is often observed in optic tact. DKI may be a more
sensitive biomarker to differentiate between MS and NMO
than conventional diffusional evaluations, such as
diffusion tensor imaging.
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