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Abstract #4519

Impact of simulated lesions on communicability metrics of the brain structural network

Jennifer Andreotti 1 , Kay Jann 1,2 , Lester Melie-Garcia 1,3 , Stphanie Giezendanner 1 , Thomas Dierks 1 , and Andrea Federspiel 1

1 Department of Psychiatric Neurophysiology, University Psychiatric Hospital, Bern, BE, Switzerland, 2 Department of Neurology, University of California Los Angeles, Los angeles, California, United States, 3 Department of Neuroinformatics, Cuban Neuroscience Center, Havana, Havana, Cuba

Communicability is a wider measure of network connectivity based on the idea that any path between two nodes will contribute to the total flow of information. Previous studies suggest that communicability may be sensitive to reorganizational changes of the brain network following a lesion. In our study the sensitivity of communicability related metrics was assessed using simulated lesions modelled as attacks to nodes and single edges. Our analysis confirmed that communicability metrics are an interesting tool to study the effects of lesions as they are sensitive to changes in the networks also in regions distant from the main lesion focus.

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