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Abstract #4518

Alteration of White Matter Networks in Unilateral Mesial Temporal Sclerosis Identified by The Whole Brain Tract-Based Automatic Analysis

Yao-Chia Shih 1,2 , Yun-Chin Hsu 2 , Horng-Huei Liu 3 , and Wen-Yih Isaac Tseng 2

1 Institute of Biomedical Engineering, National Taiwan University, Taipei, Taipei, Taiwan, 2 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 3 Department of Neurology, National Taiwan University Hospital, Taipei, Taipei, Taiwan

Patients with unilateral mesial temporal sclerosis(MTS) were shown to have extensive gray matter (GM) and white matter (WM) abnormalities ipsilateral and contralateral to the seizure onset area. The changes of the whole brain WM tracts in MTS still remain unclear. In this study, we proposed a new method to perform tract-specific analysis over the whole brain, named tract-based automatic analysis (TBAA), using a diffusion spectrum imaging (DSI) template and a tract atlas. We hypothesized that left and right MTS would affect WM tract integrity over the whole brain and have different epileptic networks. In conclusion, we successfully identified different epileptic networks in left and right MTS, and found more extensive WM alterations in right MTS than in left MTS.

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