Abstract #4518
Alteration of White Matter Networks in Unilateral Mesial Temporal Sclerosis Identified by The Whole Brain Tract-Based Automatic Analysis
Yao-Chia Shih 1,2 , Yun-Chin Hsu 2 , Horng-Huei Liu 3 , and Wen-Yih Isaac Tseng 2
1
Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taipei, Taiwan,
2
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taipei, Taiwan,
3
Department
of Neurology, National Taiwan University Hospital,
Taipei, Taipei, Taiwan
Patients with unilateral mesial temporal sclerosis(MTS)
were shown to have extensive gray matter (GM) and white
matter (WM) abnormalities ipsilateral and contralateral
to the seizure onset area. The changes of the whole
brain WM tracts in MTS still remain unclear. In this
study, we proposed a new method to perform
tract-specific analysis over the whole brain, named
tract-based automatic analysis (TBAA), using a diffusion
spectrum imaging (DSI) template and a tract atlas. We
hypothesized that left and right MTS would affect WM
tract integrity over the whole brain and have different
epileptic networks. In conclusion, we successfully
identified different epileptic networks in left and
right MTS, and found more extensive WM alterations in
right MTS than in left MTS.
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