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Abstract #4483

Reliable Analysis of Tract-specific Multiparametric MR Data via Automated Isolation of Nigro-Striatal Tract

Ryan Hutten 1 , Nisa Desai 1 , Demetrius Maraganore 2,3 , Robert R. Edelman 1,4 , and Ying Wu 1,5

1 Radiology, Northshore University Health System, Evanston, IL, United States, 2 Neurology, Northshore University Health System, IL, United States, 3 Neurology, University of Chicago, IL, United States, 4 Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 5 Radiology, University of Chicago, Chicago, IL, United States

Automated tract based diffusion tensor imaging (DTI) and magnetization transfer ratio (MTR) of the nigro-striatal tract (NST) represents a high innovative neuroimaging approach in Parkinsons disease. The NST is a major dopamine pathway that is critically involved in Parkinsons Disease (PD) diagnosis and treatment modulation. The development of the automated NST overcomes the challenges associated with segmenting SN, and the necessity of manual seed regions for tractography. We demonstrate considerably improved reliability that eliminates operator-induced error that will benefit future longitudinal studies of Parkinson's disease.

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