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Abstract #4469

Parametric representation, variability analysis and atlas construction of the mouse myocardial fiber structure

Samer Sarfaraz Merchant 1 , Arnold David Gomez 1 , and Edward Hsu 2

1 BioEngineering, University of Utah, Salt Lake City, Utah, United States, 2 University of Utah, BioEngineering, Salt Lake City, Utah, United States

Myofiber atlases have been constructed from cardiac DTI datasets using voxel-based statistics, which is prone to noise and omits obvious functional and structural interconnectivities of the organ. In the current work, parametric modeling and principal component analysis were performed to characterize and investigate the variability of myofiber structure in a group of 6 mouse hearts. Results show that the hearts can be well represented by a 16-term parametric function in prolate spheroidal space, and majority of the heart-to-heart variability exists concentrically in the transmural dimension. These findings are valuable for design and interpretation of DTI cardiac structural measurement and modeling.

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