Abstract #4469
Parametric representation, variability analysis and atlas construction of the mouse myocardial fiber structure
Samer Sarfaraz Merchant 1 , Arnold David Gomez 1 , and Edward Hsu 2
1
BioEngineering, University of Utah, Salt
Lake City, Utah, United States,
2
University
of Utah, BioEngineering, Salt Lake City, Utah, United
States
Myofiber atlases have been constructed from cardiac DTI
datasets using voxel-based statistics, which is prone to
noise and omits obvious functional and structural
interconnectivities of the organ. In the current work,
parametric modeling and principal component analysis
were performed to characterize and investigate the
variability of myofiber structure in a group of 6 mouse
hearts. Results show that the hearts can be well
represented by a 16-term parametric function in prolate
spheroidal space, and majority of the heart-to-heart
variability exists concentrically in the transmural
dimension. These findings are valuable for design and
interpretation of DTI cardiac structural measurement and
modeling.
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