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Abstract #4468

CSF contamination contributes to apparent microstructural alterations in amnestic Mild Cognitive Impairment

Rok Berlot 1,2 , Claudia Metzler-Baddeley 3 , Derek K Jones 3 , and Michael J O'Sullivan 1

1 Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom, 2 Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 3 Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, and the Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom

Partial volume effects due to cerebrospinal-fluid contamination (CSFC) lead to artefacts in diffusion MRI studies in populations prone to atrophy. We explored the influence of CSFC on apparent microstructural differences in amnestic mild cognitive impairment (MCI). A post-acquisition method of Free Water Elimination was used to correct for CSFC. Comparisons between controls and MCI were performed at several spatial levels in uncorrected and corrected data. CSFC shifted the pattern of involvement of individual temporal association tracts. Tract-based spatial statistics were robust to CSFC with notable localised exceptions. A proportion of group difference in mean histogram metrics was driven by CSFC.

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