Abstract #4430
Quantifying non-invasive MRI parameters with angiogenesis and cellular infiltration to characterize collagen-sponge remodeling
Mohammed Salman Shazeeb 1,2 , Sivakumar Kandasamy 2 , Stuart Howes 2 , and George Pins 2
1
Radiology, University of Massachusetts
Medical School, Worcester, MA, United States,
2
Biomedical
Engineering, Worcester Polytechnic Institute, Worcester,
MA, United States
Invivo evaluation of biomaterial implant remodeling
involves surgical removal of the implant for subsequent
histological assessment. This approach is often
destructive and imposes practical limitations on how
effectively these materials can be evaluated. MRI has
the potential to non-invasively monitor the remodeling
of collagen scaffolds. This study investigated the
development of a model system to quantify MRI parameters
with angiogenesis and cellular infiltration of implanted
collagen scaffolds using MRI and histological
techniques. Correlations between MRI and histological
parameters demonstrated that MRI is sensitive to
specific remodeling parameters which can aid in the
design of robust biomaterial scaffolds for tissue
regeneration.
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