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Abstract #4429

NAA spectroscopy correlates with intra-axonal compartment parameters from diffusion MRI

Elan J. Grossman 1,2 , Ivan I. Kirov 1 , Oded Gonen 1 , Dmitry S. Novikov 1 , Robert I. Grossman 1 , Matilde Inglese 3 , and Els Fieremans 1

1 Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, New York, United States, 2 Department of Physiology and Neuroscience, NYU School of Medicine, New York, New York, United States, 3 Department of Neurology, Radiology, and Neuroscience, Mount Sinai School of Medicine, New York, New York, United States

The relationship between compartment-specific white matter tract integrity (WMTI) parameters from diffusion MRI and concentrations of neurochemicals was investigated in vivo using 1H-MRS on a cohort of patients with mild traumatic brain injury (MTBI). Results demonstrated significant correlations associating n-acetylaspartate (NAA) with those WMTI parameters that are affected by intra-axonal diffusion and axonal density, suggesting the validity of a two-compartment non-exchange model of intra- and extra-axonal diffusion in a single WM fiber bundle. Our results also indicate that NAA may influence downstream processes related to axonal shrinkage, degeneration, and/or loss, as well as plasma osmolarity and myelin synthesis in MTBI.

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