Abstract #4429
NAA spectroscopy correlates with intra-axonal compartment parameters from diffusion MRI
Elan J. Grossman 1,2 , Ivan I. Kirov 1 , Oded Gonen 1 , Dmitry S. Novikov 1 , Robert I. Grossman 1 , Matilde Inglese 3 , and Els Fieremans 1
1
Center for Biomedical Imaging, Department of
Radiology, NYU School of Medicine, New York, New York,
United States,
2
Department
of Physiology and Neuroscience, NYU School of Medicine,
New York, New York, United States,
3
Department
of Neurology, Radiology, and Neuroscience, Mount Sinai
School of Medicine, New York, New York, United States
The relationship between compartment-specific white
matter tract integrity (WMTI) parameters from diffusion
MRI and concentrations of neurochemicals was
investigated in vivo using 1H-MRS on a cohort of
patients with mild traumatic brain injury (MTBI).
Results demonstrated significant correlations
associating n-acetylaspartate (NAA) with those WMTI
parameters that are affected by intra-axonal diffusion
and axonal density, suggesting the validity of a
two-compartment non-exchange model of intra- and
extra-axonal diffusion in a single WM fiber bundle. Our
results also indicate that NAA may influence downstream
processes related to axonal shrinkage, degeneration,
and/or loss, as well as plasma osmolarity and myelin
synthesis in MTBI.
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