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Abstract #4422

Changes in epithelium, stroma, and lumen space predict ADC changes with prostate cancer Gleason grade

Aritrick Chatterjee 1 , Geoff Watson 2 , Esther Myint 3 , and Roger Bourne 1

1 Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia, 2 Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia, 3 Laverty Pathology, Sydney, NSW, Australia

Reduced water ADC in cancer tissue is commonly attributed to increased cellularity, however, this explanation includes many assumptions about the diffusion properties of tissue. We hypothesise that the biophysical basis of reduced ADC in prostate cancer may instead lie in an increased partial volume of low diffusivity epithelial cells and loss of higher diffusivity stroma and lumen space. Partial volumes of epithelium, stroma, and lumen space were measured in histology images. There was a significant increase in epithelium volume and decrease in stroma and lumen space with Gleason grade. Predicted ADC changes explained about half the variation seen in vivo.

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