Abstract #4272
Brown Adipose Tissue with Low Fat Content in Newborns with Hypothermia
Houchun Harry Hu 1 , Tai-Wei Wu 2 , Larry Yin 3 , Mimi S. Kim 3 , Jonathan M. Chia 4 , Thomas G. Perkins 4 , and Vicente Gilsanz 1
1
Radiology, Children's Hospital Los Angeles,
Los Angeles, California, United States,
2
Neonatology,
Children's Hospital Los Angeles, Los Angeles,
California, United States,
3
Pediatrics,
Children's Hospital Los Angeles, Los Angeles,
California, United States,
4
Philips
Healthcare, Cleveland, Ohio, United States
We report the observation of brown adipose tissue with
low fat content in newborns with hypoxic-ischemic
encephalopathy (HIE) after hypothermia therapy treatment
in the neonatal intensive care unit. Ten HIE newborns
were studied at 3T using a six-echo
chemical-shift-encoded water-fat sequence. Fat-signal
fraction (FF) measurements of the supraclavicular brown
adipose tissue depot were compared to values from five
non-HIE newborns. The average FF range was 10.3-29.9%
and 23.7-42.2% for the HIE and non-HIE group,
respectively (p<0.01). We speculate that hypothermia
therapy in HIE neonates promotes BAT-mediated
non-shivering thermogenesis, which subsequently leads to
a depletion of the tissues intracellular fat stores.
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