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Abstract #4199

Inter-regional Differences in Brain Response Delay to End-Tidal CO2 Estimated from Resting-State fMRI

Ali M Golestani 1,2 and J Jean Chen 1,2

1 Rotman Research Institute, Baycrest, Toronto, ON, Canada, 2 University of Toronto, Toronto, ON, Canada

End-tidal CO2 (PETCO2) drives the BOLD signal. This effect is not homogeneous across brain regions, and delay maps are estimated using breath holding or other respiratory tasks, which could be uncomfortable for subjects. We investigated regional variability of PETCO2 effect by estimating the response of the resting-state BOLD signal to PETCO2 fluctuations with high temporal resolution (TR = 0.323S). We estimated the PETCO2 response at each voxel and computed the time to peak (TTP) of estimated response for multiple brain region We show that it is possible to assess brain hemodynamics using resting-state BOLD TTP in response to PETCO2.

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