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Abstract #4198

Presence of AVA in High Frequency Oscillations of the Perfusion fMRI Resting State Signal

Domenico Zac 1 , Uri Hasson 1,2 , Ben Davis 1 , Nicola De Pisapia 2 , and Jorge Jovicich 1,2

1 Center for Mind/Brain Sciences, University of Trento, Mattarello, TN, Italy, 2 Department of Psychology and Cognitive Sciences, University of Trento, TN, Italy

The Amplitude Variance Asymmetry (AVA) of the BOLD resting state signal has been demonstrated to provide reproducible nonrandom patterns of high frequency resting state activity. To investigate its neural, vascular or hemodynamic sources we studied resting state AVA from perfusion fMRI data. Perfusion-derived BOLD AVA patterns replicated previous pure BOLD findings. A significant CBF AVA pattern was also detected with similar topological features but smaller spatial extent than the BOLD AVA. These results suggest a neuronal origin of these transients as CBF measurements are more coupled with metabolism than BOLD measurements.

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