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Abstract #4111

MONITORING LOW-RISK PROSTATE CANCER WITH DIFFUSION-WEIGHTED MRI: ADC AND ITS RELATIONSHIP TO GROWTH RATE

Veronica A Morgan 1 , Chris C Parker 2 , Sharon L Giles 1 , and Nandita M de Souza 3

1 Clinical Magnetic Resonance Unit, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 2 Academic Urology, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 3 Clinical Magnetic Resonance Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom

This study evaluates the relationship between ADC and tumor growth in low risk prostate cancer patients. Tumor volume was calculated on baseline and follow-up scans of 23 patients. From the baseline scan a representative tumor ADC was also derived from a ROI drawn around the largest area of tumor. There was a significant negative correlation between tumor growth rate and ADC at presentation. In this low risk group doubling time is around 3years. Cancers with lower ADC at the outset tended to grow more quickly. Determining threshold ADCs from a larger study could influence decisions around timing of treatment.

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