Abstract #4110
Diffusion and Perfusion Coefficients Changes of Prostate Cancer after Endocrine Therapy: Using DWI Biexponential Model
Feiyu Li 1 , Wenchao Cai 1 , Jintang Ye 1 , Queenie Chan 2 , Xiaoying Wang 1 , and Xuexiang Jiang 1
1
Department of Radiology, Peking University
First Hospital, Beijing, Beijing, China,
2
Philips
Healthcare, Hong Kong, China
Accurate identification of the recurrent tumor in
prostate allows better selection of patients for salvage
or adjuvant RT after endocrine therapy. The purpose of
this study was to assess the diffusion and perfusion
coefficients changes of prostate cancer (PCa) and
noncancerous areas after endocrine therapy using DWI
biexponential model. The mean D and f values of
cancerous and noncancerous foci in the endocrine
treatment group both showed statistically different from
that in the non-treatment group. The changes of the D
and f were accordance with the pathological and
physiological degeneration of cells and vessels after
endocrine therapy in the histopathologic study. IVIM
maybe a promising technique in the better detection of
the prostate recurrent lesion after therapy.
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