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Abstract #4093

Assessment of tumor aggressiveness using intravoxel incoherent motion MRI in patients with papillary thyroid carcinoma

Yonggang Lu 1 , Ashok R. Shaha 1 , Hilda E. Stambuk 1 , Andre Moreira 1 , Yousef Mazaheri 1 , Joseph O. Deasy 1 , R. Michael Tuttle 1 , and Amita Shukla-Dave 1

1 Memorial Sloan-Kettering Cancer Center, NEW YORK, New York, United States

There is an urgent need to non-invasively assess tumor aggressiveness in patients with papillary thyroid carcinoma (PTC). In this study, pretreatment intravoxel incoherent motion imaging (IVIM) MRI was used to quantify water molecular diffusion and blood perfusion in tumor tissue of 15 patients with PTC. All patients were treated with surgery and histopathological features of aggressiveness were used as the standard of reference. The results show that IVIM MRI derived metrics were able to differentiate between aggressive and non-aggressive tumors. The study concludes that diffusion coefficient is a surrogate biomarker of tumor aggressiveness in patients with PTC.

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