Abstract #4093
Assessment of tumor aggressiveness using intravoxel incoherent motion MRI in patients with papillary thyroid carcinoma
Yonggang Lu 1 , Ashok R. Shaha 1 , Hilda E. Stambuk 1 , Andre Moreira 1 , Yousef Mazaheri 1 , Joseph O. Deasy 1 , R. Michael Tuttle 1 , and Amita Shukla-Dave 1
1
Memorial Sloan-Kettering Cancer Center, NEW
YORK, New York, United States
There is an urgent need to non-invasively assess tumor
aggressiveness in patients with papillary thyroid
carcinoma (PTC). In this study, pretreatment intravoxel
incoherent motion imaging (IVIM) MRI was used to
quantify water molecular diffusion and blood perfusion
in tumor tissue of 15 patients with PTC. All patients
were treated with surgery and histopathological features
of aggressiveness were used as the standard of
reference. The results show that IVIM MRI derived
metrics were able to differentiate between aggressive
and non-aggressive tumors. The study concludes that
diffusion coefficient is a surrogate biomarker of tumor
aggressiveness in patients with PTC.
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