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Abstract #4092

Effect of cabozantinib on K trans and v e values in castration-resistant prostate cancer

Milica Medved 1 , Aytekin Oto 1 , Xiaobing Fan 1 , Federico D Pineda 1 , Gregory S Karczmar 1 , and Russell Z Szmulewitz 2

1 Radiology, University of Chicago, Chicago, Illinois, United States, 2 Medicine, University of Chicago, Chicago, Illinois, United States

Cabozantinib shows promising results in extension of progression-free survival for men with castration-resistant prostate cancer. In this preliminary report, we document the effect of cabozantinib on perfusion in bone metastases in castration-resistant prostate cancer and in muscle tissue using the Tofts model parameters K trans and v e . We find a statistically significant decrease in lesion K trans (37% on average, p < 0.01) during the first two weeks of therapy, while other quantities were not significantly changed. It remains to be seen whether individual changes in lesion K trans can be correlated with treatment response.

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