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Abstract #4073

AMESING and BINEPT 31P MRS at 7T distinguishes glycerophosphatidylcholine from glycerophosphocholine

Wybe JM van der Kemp 1 , Bertine L Stehouwer 1 , Jurgen H Runge 2 , Jannie P Wijnen 1 , Aart J Nederveen 2 , Peter R Luijten 1 , and Dennis WJ Klomp 1

1 Radiology, UMC Utrecht, Utrecht, Netherlands, 2 Radiology, AMC, Amsterdam, Netherlands

The ratio between phosphocholine (PC), phosphoethanolamine (PE) and their glycerol compounds (GPE and GPC) are highly valuable biomarkers. However, when obtained in vivo, these signals can overlap with signals from membrane phospholipids (i.e. glycerophosphatidyl-choline (GPtC) and ethanolamine (GPtE)). Using adiabatic multi-echo (AMESING) and polarization transfer (BINEPT) techniques at 7T we demonstrate that based on chemical shift, absence of polarization transfer and reduced T2, the majority of phosphodiester signals obtained in breast tissue originate from GPtC and GPtE rather than from the GPE and GPC.

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