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Abstract #4059

Intravoxel Incoherent Motion MRI for Tumor Subtype Differentiation in Locally Advanced Breast Cancer

Gene Young Cho 1,2 , Linda Moy 1,3 , Sungheon Kim 1 , Ana Paula Klautau Leite 4 , Steven Baete 1 , Jim Babb 1 , Daniel K Sodickson 1 , and Eric E Sigmund 1

1 Radiology - Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, Select, United States, 2 Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States, 3 Radiology, New York University Cancer Institute, New York, NY, United States, 4 Radiology, Hospital das Clnicas, School of Medicine, University of So Paulo, So Paulo, SP, Brazil

An accurate, simple method using imaging to determine cancer type has long been a goal in oncology. Determination of tumor subtypes through imaging can be advantageous in the strategic planning of therapy and limit the need for invasive biopsy procedures. In MRI, intravoxel incoherent motion (IVIM) can play an important role as it is most commonly employed due to its sensitivity to tumor cell density and vascularity, both components of aggressiveness. In this study, highly sampled DWI data is used to perform IVIM analysis in a cohort of breast cancer patients in a 3T clinical scanner.

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