Abstract #4058
Comparison of MRI tumour diameter and volume changes with apparent diffusion coefficient (ADC) values in prediction of pathological response following neoadjuvant chemotherapy (NACT)
Sara Vigano' 1,2 , Andrew J. Patterson 3 , Mary McLean 4 , Elena Provenzano 5 , Louise Hiller 6 , Janet Dunn 6 , Anne-Laure Vallier 7 , Louise Grybowicz 7 , Reem Bedair 8 , Matthew G Wallis 9 , Martin J Graves 10 , Helena Earl 11 , and Fiona J Gilbert 8
1
Cambridge University Hospitals NHS
Foundation Trust, Cambridge, United Kingdom,
2
Universita'
degli Studi di Milano, Milano, Italy,
3
Radiology,
Cambridge University Hospitals NHS Foundation Trust,
Cambridge, United Kingdom,
4
CRUK
Cambridge Institute, University of Cambridge, United
Kingdom,
5
Department
of Histopathology and Cambridge Breast Unit, Cambridge
University Hospital NHS Foundation Trust and NIHR
Cambridge Biomedical Research Centre, United Kingdom,
6
Warwick
Clinical Trials Unit, University of Warwick, Coventry,
United Kingdom,
7
Department
of Oncology, Cambridge Cancer Trials Centre, Cambridge
Breast Unit, Cambridge University Hospitals NHS
Foundation Trust, United Kingdom,
8
Radiology,
University of Cambridge, Cambridge, United Kingdom,
9
Cambridge
Breast Unit and NIHR Biomedical Research centre,
Cambridge University Hospitals NHS Foundation Trust,
Cambridge, United Kingdom,
10
Radiology,
Cambridge University Hospital NHS Foundation Trust and
NIHR Cambridge Biomedical Research Centre, United
Kingdom,
11
Department
of Oncology, NIHR Cambridge Biomedical Research Centre
and Cambridge Breast Unit, University of Cambridge,
Cambridge, United Kingdom
Assessing and predicting neoadjuvant chemotherapy
response is extremely important. Our aim was to compare
changes in morphologic MR parameters and ADC values
between responders and non-responders over time.
Forty-five breast cancer patients had MRI at baseline,
after the third cycle (mid-treatment), and at
end-treatment. Tumor diameter, total volume and ADC
values were compared between responders and
non-responders. Changes in tumour volume and ADC
significantly differed at end-treatment (p=0.007 and
p<0.001), but at mid-treatment only ADC values showed
significant changes (p=0.001). Morphologic parameters
and ADC may be used in monitoring response but ADC may
be an earlier predictor of pathological outcome.
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