Abstract #4047
Extracellular sodium MRI, a non-invasive endogenous marker for tumoral response to photodynamic therapy associated with nitroglycerin.
Carole D. Thomas 1,2 , Florent Poyer 1,2 , Philippe Maillard 1,3 , Mihaela Lupu 1,2 , and Joel Mispelter 1,2
1
Institut Curie, Orsay, France,
2
INSERM
U759, Orsay, France,
3
CNRS
UMR176, Orsay, France
The aim of this study was double. Firstly, to determine
if photodynamic therapy associated with nitroglycerin
ointment was able to induce a major cellular death on a
tumoral line of retinoblastoma that was less responsive
to treatment. Secondly to determine if extracellular MRI
follow-up is able to give rapid information about tumor
cells destruction. Nitroglycerin increased the
photosensitzer concentration at the tumor level and
hence the treatment efficiency. Sodium MRI monitored
non-invasively the cellular destruction, showing a local
increase of sodium concentration specific to
extracellular sodium amount all over where cells were
irreversible damaged by PDT.
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