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Abstract #4047

Extracellular sodium MRI, a non-invasive endogenous marker for tumoral response to photodynamic therapy associated with nitroglycerin.

Carole D. Thomas 1,2 , Florent Poyer 1,2 , Philippe Maillard 1,3 , Mihaela Lupu 1,2 , and Joel Mispelter 1,2

1 Institut Curie, Orsay, France, 2 INSERM U759, Orsay, France, 3 CNRS UMR176, Orsay, France

The aim of this study was double. Firstly, to determine if photodynamic therapy associated with nitroglycerin ointment was able to induce a major cellular death on a tumoral line of retinoblastoma that was less responsive to treatment. Secondly to determine if extracellular MRI follow-up is able to give rapid information about tumor cells destruction. Nitroglycerin increased the photosensitzer concentration at the tumor level and hence the treatment efficiency. Sodium MRI monitored non-invasively the cellular destruction, showing a local increase of sodium concentration specific to extracellular sodium amount all over where cells were irreversible damaged by PDT.

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