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Abstract #4020

Application of a SAGE Sequence During Isometric Contractions in Skeletal Muscle

Christopher P. Elder 1,2 , Jack T. Skinner 1,3 , Theodore F. Towse 2,3 , Nathan D. Bryant 1,3 , and Bruce M. Damon 1,3

1 Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, United States, 2 Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, TN, United States, 3 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Subtracting the time-courses of R2* and R2 from separate image acquisitions yields an estimate of R2 that can be used for image-based calculation of muscle oxyhemoglobin saturation. An EPI based multiple spin- and gradient-echo (SAGE) method developed for brain perfusion imaging permits simultaneous measurement of R2* and R2. We applied the SAGE sequence to measurements of relaxation rates in skeletal muscle during maximal and submaximal isometric dorsiflexion contractions. Baseline SAGE R2* and R2 measurements agree with conventional multi-echo measurements. SAGE allows more direct measurement of R2* and R2 related to the BOLD effect in skeletal muscle induced by isometric contractions.

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