Abstract #4002
Assessment of an In Vitro Animal Model for Intervertebral Disc Degeneration Using MR Elastography
Ephraim I Ben-Abraham 1 , Jun Chen, Ph.D. 1 , and Richard L Ehman, M.D. 1
1
Radiology, Mayo Clinic, Rochester, MN,
United States
Low back pain (LBP) is a very costly and prevalent
health disorder in the U.S. One of the most common
causes of LBP is degenerative disc disease (DDD). It is
known that the stiffness of the disc changes
substantially with degeneration. MRE has been
demonstrated for estimating the shear stiffness of the
nucleus in the intervertebral disc in vitro. In this
study, we investigate the change in nucleus stiffness
caused by an in vitro, enzymatically-induced animal
model for disc degeneration using MRE. Our results
showed a substantial increase in the nucleus shear
stiffness with the induced disc degeneration.
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