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Abstract #3993

3D UTE MRI derived porosity index as a practical approach to assess cortical bone porosity in human subjects

Mahdieh Bashoor-Zadeh 1 , Chamith S. Rajapakse 1 , Cheng Li 1 , Wenli Sun 1 , Alexander C. Wright 1 , and Felix W. Wehrli 1

1 Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

Cortical bone porosity is underestimated even with the current state of the art human bone imaging modalities due to resolution limitations. Here, we pursue an UTE imaging approach by collecting only two echoes (TE=50s and 2000s) as part of a single scan based on the notion that the first echo contains total bone water, the second predominantly pore water yielding a porosity index as the ratio of the two signal amplitudes. In cadaveric human cortical bone, porosity index was found to correlate strongly with CT-derived porosity and pore volume fraction obtained by laborious Laplace inversion of multi-echo UTE signal.

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