Abstract #3993
3D UTE MRI derived porosity index as a practical approach to assess cortical bone porosity in human subjects
Mahdieh Bashoor-Zadeh 1 , Chamith S. Rajapakse 1 , Cheng Li 1 , Wenli Sun 1 , Alexander C. Wright 1 , and Felix W. Wehrli 1
1
Department of Radiology, University of
Pennsylvania School of Medicine, Philadelphia,
Pennsylvania, United States
Cortical bone porosity is underestimated even with the
current state of the art human bone imaging modalities
due to resolution limitations. Here, we pursue an UTE
imaging approach by collecting only two echoes (TE=50s
and 2000s) as part of a single scan based on the notion
that the first echo contains total bone water, the
second predominantly pore water yielding a porosity
index as the ratio of the two signal amplitudes. In
cadaveric human cortical bone, porosity index was found
to correlate strongly with CT-derived porosity and pore
volume fraction obtained by laborious Laplace inversion
of multi-echo UTE signal.
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