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Abstract #3992

Bone Mineral and Matrix Densities Measured by Solid-State 1H and 31P MRI

Alan C. Seifert 1 , Cheng Li 1 , Chamith S. Rajapakse 1 , Mahdieh Bashoor-Zadeh 1 , Yusuf A. Bhagat 1 , Alexander C. Wright 1 , Babette Zemel 2 , Antonios Zavaliangos 3 , and Felix W. Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 GI, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 3 Materials Science and Engineering, Drexel University, Philadelphia, PA, United States

Osteoporosis and osteomalacia both manifest as reduced apparent bone mineral density. The differentiating factor is mineral per volume of matrix. Advances in solid-state MRI have led to the possibility of quantitative bone mineral 31P and collagen-bound water 1H density measurement. Sixteen fully-mineralized human bone specimens were scanned with 31P ZTE and 1H Adiabatic Inversion-Recovery ZTE, and 31P and bound water densities were quantified relative to reference phantoms. Both densities correlate negatively with age and porosity, and positively with pQCT density, and as expected, the ratio of 31P to bound water density does not correlate with age, porosity, or pQCT density.

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