Abstract #3962
Comparisons of Canine ECV Measurements by CMR at 3T: IR- vs. SR-based Cardiac T1 Mapping and Bolus Injection vs. Slow Infusion of Contrast Agent
Kyungpyo Hong 1,2 , Eugene G. Kholmovski 1 , Derek J. Dosdall 3 , Christopher J. McGann 3 , Ravi Ranjan 3 , and Daniel Kim 1
1
UCAIR, Department of Radiology, University
of Utah, Salt Lake City, Utah, United States,
2
Department
of Bioengineering, University of Utah, Salt Lake City,
Utah, United States,
3
CARMA,
Department of Internal Medicine, University of Utah,
Salt Lake City, Utah, United States
While extracellular volume fraction (ECV) derived from
hematocrit and pre- and post-contrast T1 measurements is
an emerging method for assessment of diffuse cardiac
fibrosis, systematic studies investigating the technical
nuance are largely lacking. In well controlled canine
experiment, we sought to compare ECV measurements
between IR-based and SR-based cardiac T1 mapping pulse
sequences, and ECV measurements between bolus injection
and slow infusion protocols. Our results suggest that IR-
and SR-based cardiac T1 mapping pulse sequences yield
significantly different T1 and ECV measurements, and
that 15 min after a bolus injection may not be dynamic
equilibrium of contrast agent in canines.
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