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Abstract #3961

Cardiac ECV is More Robust than Post-Contrast Cardiac T1 for Evaluating Temporal Changes in Left Ventricular Fibrosis

Kyungpyo Hong 1,2 , Matthias Koopmann 3 , Eugene G. Kholmovski 1 , Eric C. Huang 4 , Nan Hu 5 , Richard Levenson 4 , Sathya Vijayakumar 1 , Derek J. Dosdall 6 , Ravi Ranjan 6 , and Daniel Kim 1

1 UCAIR, Department of Radiology, University of Utah, Salt Lake City, Utah, United States, 2 Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States, 3 Department of Cardiovascular Medicine, University Hospital of Mnster, Mnster, Germany, 4 Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California, United States, 5 Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States, 6 CARMA, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States

While post-contrast cardiac T1 has been shown to be inversely correlated with interstitial fibrosis, it may be influenced by various confounders. Despite the theoretical advantages of extracellular volume (ECV) measurement for compensating confounders, systematic studies comparing post-contrast T1 and ECV are lacking. We sought to compare the effectiveness of post-contrast cardiac T1 and ECV for evaluating the temporal changes of left ventricular (LV) fibrosis in canine models with chronic atrial fibrillation. Compared with histologic quantification of interstitial fibrosis, ECV agreed better than post-contrast LV T1, suggesting that ECV is a more robust measure of extracellular space than post-contrast LV T1.

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