Abstract #3901
The Impact of Cystic Fibrosis on Cardiac Function and Stress Response
Kai Jiang 1,2 , Sen Jiao 1,2 , Craig A. Hodges 3,4 , Rebecca Darrah 4 , and Xin Yu 1,5
1
Department of Biomedical Engineering, Case
Western Reserve University, Cleveland, OH, United
States,
2
Case
Medical Center, Case Western Reserve University,
Cleveland, Ohio, United States,
3
Department
of Pediatrics, Case Western Reserve University,
Cleveland, Ohio, United States,
4
Department
of Genetics and Genome Sciences, Case Western Reserve
University, Cleveland, Ohio, United States,
5
Department
of Radiology, Case Western Reserve University,
Cleveland, Ohio, United States
In this study, cardiac function of two mouse models of
cystic fibrosis (CF) was characterized both in vivo and
in vitro. An increase in ventricular torsion was
observed in CF mice at baseline. However, CF mice showed
reduced response to β-adrenergic stimulation. Myocyte
contractility and Ca
2+
transients were similar
between the CF mice and the controls, suggesting that
the observed increase in ventricular torsion in CF mice
might be due to changes in ventricular structure.
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