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Abstract #3843

Models of pulmonary vascular resistance in pulmonary hypertension from pulse wave analysis of MRI measurements in the main pulmonary artery

Angela Lungu 1 , Jim Wild 1 , Andy Swift 1 , David Capener 1 , David Kiely 2 , and Rod Hose 1

1 Cardiovascular Science, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Pulmonary Vascular Disease Unit, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Pulmonary hypertension (PH) is a disease characterised by increased mean pulmonary arterial pressure measured by invasive right heart catheterisation. Temporally and spatially registered images, from two separate MR sequences (phase contrast and bSSFP) were acquired in patients with suspected PH, and in healthy volunteers. Anatomical and flow measurements were obtained throughout the cardiac cycle. The computed waveforms were combined with mathematical models (based on an electrical impedance analogy and wave reflection quantification) to assess the status of the pulmonary circulation. Our results demonstrate that the proposed method has the potential to non-invasively distinguish between normal and clinically stratified PH groups.

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