Abstract #3842
Beta-Blocker Therapy Alters 3D Wall Shear Stress in the Ascending Aorta of Patients with Bicuspid Aortic Valve
Bradley D Allen 1 , Pim van Ooij 1 , Alex J Barker 1 , Jeremy D Collins 1 , James C Carr 1 , S. Chris Malaisrie 2 , Patrick McCarthy 2 , Jyothy Puthumana 3 , Preeti Kansal 3 , and Michael Markl 1,4
1
Department of Radiology, Northwestern
University, Chicago, IL, United States,
2
Division
of Surgery - Cardiac Surgery, Northwestern University,
Chicago, IL, United States,
3
Department
of Medicine - Cardiology, Northwestern University,
Chicago, IL, United States,
4
Department
of Biomedical Engineering, Northwestern University,
Chicago, IL, United States
Patients with bicuspid aortic valve (BAV) are at
increased risk of ascending aorta aneurysm development
and wall shear stress (WSS) has been hypothesized to be
a driver of vascular remodeling and aneurysm
progression. Beta-blockers are the guideline-recommended
medical therapy to slow aortic dilation in this patient
group. In this study, we calculated 3D WSS in the aorta
of BAV patients on or not on beta-blockers. We found a
trend toward reduced WSS in patients taking
beta-blockers, suggesting that a reduction in WSS may be
the mechanism by which beta-blockers effectively slow
aortic dilatation.
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