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Abstract #3803

Single voxel localization for dynamic hyperpolarized 13C MR spectroscopy

Albert P Chen 1 and Charles H Cunningham 2,3

1 GE Healthcare, Toronto, ON, Canada, 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3 Medical Biophysics, University of Toronto, Toronto, ON, Canada

PRESS technique has been widely used to achieve voxel localization for in vivo 1H MRS acquisitions, but for dynamic hyperpolarized 13C MRS experiments, the transition bands of the refocusing pulses may prematurely saturate the pre-polarized substrate spins moving into the voxel. This limitation may be overcame by designing refocusing pulses that do not perturb the resonance of the hyperpolarized substrate but refocuses the spins of the metabolic products. In this study, a PRESS pulse sequence incorporating spectral-spatial refocusing pulses that have a stop band (notch) at the substrate resonance is tested in vivo using hyperpolarized [1-13C]pyruvate.

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