Abstract #3803
Single voxel localization for dynamic hyperpolarized 13C MR spectroscopy
Albert P Chen 1 and Charles H Cunningham 2,3
1
GE Healthcare, Toronto, ON, Canada,
2
Imaging
Research, Sunnybrook Health Sciences Centre, Toronto,
ON, Canada,
3
Medical
Biophysics, University of Toronto, Toronto, ON, Canada
PRESS technique has been widely used to achieve voxel
localization for in vivo 1H MRS acquisitions, but for
dynamic hyperpolarized 13C MRS experiments, the
transition bands of the refocusing pulses may
prematurely saturate the pre-polarized substrate spins
moving into the voxel. This limitation may be overcame
by designing refocusing pulses that do not perturb the
resonance of the hyperpolarized substrate but refocuses
the spins of the metabolic products. In this study, a
PRESS pulse sequence incorporating spectral-spatial
refocusing pulses that have a stop band (notch) at the
substrate resonance is tested in vivo using
hyperpolarized [1-13C]pyruvate.
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