Abstract #3768
Neuroprotective effect of Lactoferrin following inflammatory injury in the developing rat brain assessed by high-field 1 H-MR Spectroscopy
Yohan van de Looij 1,2 , Vanessa Ginet-Puyal 1 , Rolf Gruetter 2,3 , Petra S Hppi 1 , and Stphane V Sizonenko 1
1
Division of Child Growth and Development,
University of Geneva, Geneva, GE, Switzerland,
2
Laboratory
for Functional and Metabolic Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne, VD,
Switzerland,
3
Department
of Radiology, University of Geneva and Lausanne, Geneva
and Lausanne, GE and VD, Switzerland
Lactoferrin (Lf) is an iron-binding glycoprotein
secreted in milk known as antioxydant, anti-inflammatory
and antimicrobial. The aim of this work was to assess by
1H-MRS neuroprotective effects of Lf during lactation on
3 days-old pup rats (corresponding to human preterm born
at 24-28 weeks of gestation) injected with
Lipopolysaccharide (LPS) in the corpus callosum. Results
show a partial neuroprotection of Lf supplemented in
food during lactation following LPS exposure with less
compromised metabolism and reduced ventriculomegaly.
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