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Abstract #3767

In vivo 1 H MRS of Dynamic 13 C Labeling of Glutamate and Glutamine

Li An 1 , Shizhe Li 1 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , James B Murdoch 2 , and Jun Shen 1

1 National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 2 Toshiba Medical Research Institute USA, Mayfield Village, OH, United States

The feasibility of using a proton-only pulse sequence to measure dynamic glutamate and glutamine labeling process during infusion of 13 C labeled glucose at 7T was demonstrated by numerical simulations and in vivo experiments on two healthy volunteers. Compared to conventional proton-observed 13 C-edited experiments, the proton-only pulse sequence is much simpler in hardware and software requirements since it is a pure 1 H pulse sequence with no RF pulses at 13 C resonances.

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